Nicorandil can induce severe oral ulceration
Identifieur interne : 002B05 ( Istex/Curation ); précédent : 002B04; suivant : 002B06Nicorandil can induce severe oral ulceration
Auteurs : Crispian Scully ; Antonio Mano Azul ; Alexander Crighton ; David Felix ; Anne Field ; Stephen R. PorterSource :
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology [ 1079-2104 ] ; 2001.
Descripteurs français
- Wicri :
- topic : Maladie cardio-vasculaire.
English descriptors
- KwdEn :
- Adverse effects, Angina, Angina pectoris, Aphthous, Aphthous ulcers, Buccal, Buccal mucosa, Buccal mucosa tongue, Buccal tongue, Cardiovascular disease, Cutaneous, Diameter ulcer, European countries, Full blood count, Genital, Genital lesions, Glyceryl trinitrate spray, Incisional biopsy, Inhibitor, Ischemic heart disease, Isosorbide mononitrate, Labial, Lesion, Medical history, Mouth ulcers, Nicorandil, Nicorandil therapy, Nonspecific features, Normal limits, Ocular, Oral biol, Oral medicine, Oral pathol, Oral surg, Oral surgery, Oral ulceration, Pathology february, Pathology volume, Previous history, Scully, Severe mouth ulceration, Soft palate, Ulcer, Ulceration.
- Teeft :
- Adverse effects, Angina, Angina pectoris, Aphthous, Aphthous ulcers, Buccal, Buccal mucosa, Buccal mucosa tongue, Buccal tongue, Cardiovascular disease, Cutaneous, Diameter ulcer, European countries, Full blood count, Genital, Genital lesions, Glyceryl trinitrate spray, Incisional biopsy, Inhibitor, Ischemic heart disease, Isosorbide mononitrate, Labial, Lesion, Medical history, Mouth ulcers, Nicorandil, Nicorandil therapy, Nonspecific features, Normal limits, Ocular, Oral biol, Oral medicine, Oral pathol, Oral surg, Oral surgery, Oral ulceration, Pathology february, Pathology volume, Previous history, Scully, Severe mouth ulceration, Soft palate, Ulcer, Ulceration.
Abstract
Abstract: Objective: To increase physicians’ and dentists’ awareness that nicorandil is a potential inducer of severe mouth ulceration. Study Design: Nine new cases of ulceration from 3 European countries were included in this study. Results: Oral ulceration developed within 9 months of beginning nicorandil therapy, and ulcers resolved within 1 month of withdrawal of the drug. No lesions developed on other epithelia. Conclusions: A number of drugs used in the care of patients with cardiovascular disease can cause oral adverse effects. Nicorandil, a new potassium-channel activator used in some countries to treat angina pectoris, precipitates persistent ulcerative stomatitis in some patients. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:189-93)
Url:
DOI: 10.1067/moe.2001.110306
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Crispian Scully<affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nicorandil can induce severe oral ulceration</title><author><name sortKey="Scully, Crispian" sort="Scully, Crispian" uniqKey="Scully C" first="Crispian" last="Scully">Crispian Scully</name><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Azul, Antonio Mano" sort="Azul, Antonio Mano" uniqKey="Azul A" first="Antonio Mano" last="Azul">Antonio Mano Azul</name><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Crighton, Alexander" sort="Crighton, Alexander" uniqKey="Crighton A" first="Alexander" last="Crighton">Alexander Crighton</name><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Felix, David" sort="Felix, David" uniqKey="Felix D" first="David" last="Felix">David Felix</name><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Field, Anne" sort="Field, Anne" uniqKey="Field A" first="Anne" last="Field">Anne Field</name><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Porter, Stephen R" sort="Porter, Stephen R" uniqKey="Porter S" first="Stephen R." last="Porter">Stephen R. Porter</name><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:577EE3918EF776A8D8061E663F0E81F8C1CC987A</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1067/moe.2001.110306</idno><idno type="url">https://api.istex.fr/document/577EE3918EF776A8D8061E663F0E81F8C1CC987A/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002B05</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002B05</idno><idno type="wicri:Area/Istex/Curation">002B05</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Nicorandil can induce severe oral ulceration</title><author><name sortKey="Scully, Crispian" sort="Scully, Crispian" uniqKey="Scully C" first="Crispian" last="Scully">Crispian Scully</name><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Azul, Antonio Mano" sort="Azul, Antonio Mano" uniqKey="Azul A" first="Antonio Mano" last="Azul">Antonio Mano Azul</name><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Crighton, Alexander" sort="Crighton, Alexander" uniqKey="Crighton A" first="Alexander" last="Crighton">Alexander Crighton</name><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Felix, David" sort="Felix, David" uniqKey="Felix D" first="David" last="Felix">David Felix</name><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Field, Anne" sort="Field, Anne" uniqKey="Field A" first="Anne" last="Field">Anne Field</name><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Porter, Stephen R" sort="Porter, Stephen R" uniqKey="Porter S" first="Stephen R." last="Porter">Stephen R. Porter</name><affiliation><mods:affiliation>London and Liverpool, England; Dundee and Glasgow, Scotland; and Lisbon, PortugalUNIVERSITY COLLEGE LONDON, CAMPUS UNIVERSITáRIO-QUINTA DA GRANJA, EASTMAN DENTAL INSTITUTE, DUNDEE DENTAL HOSPITAL AND SCHOOL, GLASGOW DENTAL HOSPITAL AND SCHOOL, AND LIVERPOOL UNIVERSITY DENTAL HOSPITAL aDepartment of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London. bDepartment of Special Terapheutics, Instituto Superior de Ciências da Saúde—Sul, Campus Universitário—Quinta da Granja Monte da Caparica, Portugal. cDepartment of Dental Surgery, Dundee Dental Hospital and School. dDepartment of Oral Medicine, Glasgow Dental Hospital and School. eLiverpool University Dental Hospital</mods:affiliation><wicri:noCountry code="subField">Hospital</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology</title><title level="j" type="abbrev">YMOE</title><idno type="ISSN">1079-2104</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">91</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="189">189</biblScope><biblScope unit="page" to="193">193</biblScope></imprint><idno type="ISSN">1079-2104</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1079-2104</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adverse effects</term><term>Angina</term><term>Angina pectoris</term><term>Aphthous</term><term>Aphthous ulcers</term><term>Buccal</term><term>Buccal mucosa</term><term>Buccal mucosa tongue</term><term>Buccal tongue</term><term>Cardiovascular disease</term><term>Cutaneous</term><term>Diameter ulcer</term><term>European countries</term><term>Full blood count</term><term>Genital</term><term>Genital lesions</term><term>Glyceryl trinitrate spray</term><term>Incisional biopsy</term><term>Inhibitor</term><term>Ischemic heart disease</term><term>Isosorbide mononitrate</term><term>Labial</term><term>Lesion</term><term>Medical history</term><term>Mouth ulcers</term><term>Nicorandil</term><term>Nicorandil therapy</term><term>Nonspecific features</term><term>Normal limits</term><term>Ocular</term><term>Oral biol</term><term>Oral medicine</term><term>Oral pathol</term><term>Oral surg</term><term>Oral surgery</term><term>Oral ulceration</term><term>Pathology february</term><term>Pathology volume</term><term>Previous history</term><term>Scully</term><term>Severe mouth ulceration</term><term>Soft palate</term><term>Ulcer</term><term>Ulceration</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adverse effects</term><term>Angina</term><term>Angina pectoris</term><term>Aphthous</term><term>Aphthous ulcers</term><term>Buccal</term><term>Buccal mucosa</term><term>Buccal mucosa tongue</term><term>Buccal tongue</term><term>Cardiovascular disease</term><term>Cutaneous</term><term>Diameter ulcer</term><term>European countries</term><term>Full blood count</term><term>Genital</term><term>Genital lesions</term><term>Glyceryl trinitrate spray</term><term>Incisional biopsy</term><term>Inhibitor</term><term>Ischemic heart disease</term><term>Isosorbide mononitrate</term><term>Labial</term><term>Lesion</term><term>Medical history</term><term>Mouth ulcers</term><term>Nicorandil</term><term>Nicorandil therapy</term><term>Nonspecific features</term><term>Normal limits</term><term>Ocular</term><term>Oral biol</term><term>Oral medicine</term><term>Oral pathol</term><term>Oral surg</term><term>Oral surgery</term><term>Oral ulceration</term><term>Pathology february</term><term>Pathology volume</term><term>Previous history</term><term>Scully</term><term>Severe mouth ulceration</term><term>Soft palate</term><term>Ulcer</term><term>Ulceration</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Maladie cardio-vasculaire</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Objective: To increase physicians’ and dentists’ awareness that nicorandil is a potential inducer of severe mouth ulceration. Study Design: Nine new cases of ulceration from 3 European countries were included in this study. Results: Oral ulceration developed within 9 months of beginning nicorandil therapy, and ulcers resolved within 1 month of withdrawal of the drug. No lesions developed on other epithelia. Conclusions: A number of drugs used in the care of patients with cardiovascular disease can cause oral adverse effects. Nicorandil, a new potassium-channel activator used in some countries to treat angina pectoris, precipitates persistent ulcerative stomatitis in some patients. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:189-93)</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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